What is cannabidiol, or CBD?
Cannabidiol is one of several cannabinoids, chemical substances found in cannabis plants. Although there are several cannabinoids, CBD and tetrahydrocannabinol (THC) are the two that are most widely known. THC is found in large quantities in marijuana plants – it’s the cannabinoid that’s responsible for most of the psychoactive effects that cause marijuana users to get “high”. Cannabidiol also is found in marijuana plants but only at low levels. The primary source of CBD in nature is the hemp plant, a botanical cousin to marijuana.
How does CBD work?
Many cells in the body have what are called cannabinoid receptors, protein molecules on a cell’s surface that react when they come in contact with certain chemical substances. Different receptors react with different substances to cause different reactions – for instance, the release of a hormone or other chemical. The cells that react with cannabinoids comprise what’s known as the endocannabinoid system. When these receptors are activated, they exert an effect on mood, pain sensation, appetite and other biologic responses.
What’s the difference between CBD oil from hemp and CBD oil from marijuana?
First of all, hemp contains naturally high levels of CBD and low levels of THC while marijuana produces low levels of CBD and high levels of THC. To get CBD oil from marijuana, special strains must be developed and hybridized, which means the oil is not being derived from a source that occurs in nature.
Second, CBD oil from hemp is legal while CBD oil from marijuana is only legal in specific countries and for the treatment of specific disorders – mostly those involving seizures.
Third, because hemp contains much higher levels of CBD compared to marijuana, extracting it is much simpler – and much less costly. Therefore, it’s available at a much lower cost.
Finally, while CBD oil from hemp suffers from some image problems, thanks to its link with marijuana, its use as a supplement is still far more socially acceptable and less controversial than CBD oil from its cousin.
Why do so many people prefer CBD from hemp compared to CBD from marijuana?
Well, primarily because it’s just simpler to get. Because it’s legal, it can be purchased without a perscription. Second, many people prefer the natural aspect of CBD oil found in hemp, which doesn’t need to be coaxed or altered in order to derive high levels of CBD from it. CBD oil from hemp is pure, which means the levels of THC and other trace compounds are miniscule. That means you can count on getting the effects of CBD without experiencing unwanted side effects. And finally, because hemp-derived CBD oil has been used for so long medicinally, many people trust it more than CBD oil from hybridized pot strains, which have only recently begun to be explored as a medicinal product.
What conditions does CBD treat?
There are literally dozens of uses that CBD has been know to treat.
Clinical studies have also found that our bodys own CBD receptors play a significant role in many health and medical conditions, including; but not limited too:
ADD and ADHD
Clinical Endocannabinoid Deficiency Syndrome (CEDS)
Epilepsy and other Seizure Disorders
High Blood Pressure(Hypertension)
Irritable Bowel Syndrome
Multiple Sclerosis (MS)
Mutated Cells (Tumors, Polyps, Warts)
Prion/Mad Cow Disease
Sickle Cell Anemia
Sleep Disorders (Insomnia)
Spinal Cord Injury
Stroke and TBI
Common Health Benefits of CBD (cannabidiol)
Scientific research now shows the many health benefits of CBD; Cannabidiol is a component of marijuana but it does not produce the psychoactive effects that have made marijuana attractive for recreational use. CBD benefits are real because CBD does produce strong medicinal and therapeutic effects for even the most common conditions.
A healthy appetite is vital to a healthy body, especially when the body is healing. Some illnesses decrease the appetite to the point of preventing the body from healing itself. CBD stimulates appetite, according to the National Cancer Institute. In the human body, CBDs bind to cannabinoid receptors in the body. Scientists believe these receptors play an important role in regulating feeding behavior. CBDs stimulate appetite when they dock onto these receptors.
CBD also eases nausea and vomiting. This is especially helpful for individuals enduring chemotherapy and other treatments for serious diseases.
CBDs bind to CB1 receptors in the body to relieve pain. CBD also has an anti-inflammatory effect that reduces swelling.
CBD may alleviate severe social anxiety. Generalized Social Anxiety Disorder, or SAD, is one of the most common forms of anxiety disorders that impair quality of life. Some consumers complain of increased social anxiety after marijuana use but this may be due to low levels of CBD proportionate to the higher levels of THC.
In a 2011 study, scientists wanted to study the effects of CBD on people with SAD. The scientists selected 24 people with this condition who had never received treatment for SAD then divided participants into two groups. One group received 600 mg of CBD while the control group received a placebo. The scientists then asked study participants to take part in a simulated public speaking test while researchers measured blood pressure, heart rate and other measurements of physiological and psychological stress.
The CBD group showed significantly reduced anxiety, cognitive impairment and discomfort in their speech performance. In comparison, those in the placebo group presented higher anxiety, cognitive impairment and discomfort.
According to the National Institute of Mental Health, approximately 15 million adults in the United States alone have social phobia and about 6.8 million have a generalized anxiety disorder. Traditional treatment usually involves counseling and medications. Treatment with CBD may be better than anti-depressants because it acts quickly and does not cause side effects or withdrawal symptoms.
The National Cancer Institute details several studies into the anti-tumor effects of CBD. One study in mice and rats suggest CBDs “may have a protective effect against the development of certain types of tumors.” CBDs may do this by inducing tumor cell death, inhibiting cancer cell growth, and by controlling and inhibiting the spread of cancer cells.
One study by California Pacific Medical Center suggests CBD “turns off” the gene involved in the spread of breast cancer. These scientists found CBD inhibits ID-1, an action that prevents cancer cells from traveling long distances to distant tissues.
CBD relieves psychotic symptoms associated with schizophrenia, according to research by University of Cologne in Germany. Schizophrenia affects about 1.1 percent of the population, or approximately 2.4 million adults in the United States alone.
CBD continues to surprise medical researchers with the variety of common health benefits it provides. An increasing number of scientists, physicians and consumers are learning about these health benefits and incorporating CBD into a healthy lifestyle plan.
What is the Clinical Endocannabinoid Deficiency Syndrome (CEDS)?
Clinical Endocannabinoid Deficiency Syndrome (CEDS) is an umbrella term for a group of illnesses, including fibromyalgia, migraine and irritable bowel syndrome. A growing number of respected scientists in the medical community think low levels of endocannabinoids are the root cause of these devastating conditions. Medscape says there is scientific evidence suggesting endocannabinoids play a role in inflammation, insulin sensitivity, and fat and energy metabolism.
What Are Endocannabinoids?
Human and animal bodies synthesize endocannabinoids naturally. In fact, the prefix “endo” means “made in the body”. Endocannabinoids are part of the larger endocannabinoid system that regulates appetite, pain sensation, mood, memory, and more.
There are three basic parts to the endocannabinoid system:
Enzymes that Control Endocannabinoid Levels
Enzymes regulate endocannabinoid levels by stimulating the synthesis of endocannabinoid to raise levels or signal endocannabinoid destruction to lower levels.
Endocannabinoids are lipids, which are a special type of fat that interacts with the nervous system to cause specific changes in the body. Endocannabinoids latch onto special endocannabinoid receptor cells to make these changes in the nervous system happen. This action is somewhat like a captain docking his boat at a marina. Receptor cells are located throughout the body.
All mammals produce endocannabinoids that bind to endocannabinoid receptors. There are two types of endocannabinoids – anandamide and 2-AG. Each of these binds to specific endocannabinoid receptors; anandamide latches onto CB1 receptors and 2-AG docks onto CB2 receptor cells. CB1 are more common in vital organs while CB2 are more prevalent in peripheral cells and in the immune system.
The marijuana plant produces a similar substance – cannabinoids such as CBD Cannabidiol; that bind to these receptors too. When cannabinoids bind to these receptors, they produce a pleasant euphoria. However, when endocannabinoids bind to these receptors they have a therapeutic effect that helps various body systems run more effectively. High or low endocannabinoid levels can cause body systems to function poorly. Substantially low endocannabinoid levels can cause symptoms of CEDS.
Research published in Neuroendocrinology Letters reviewed scientific publications to study the concept of CEDS and the possibility that endocannabinoid deficiency can cause migraine, fibromyalgia, irritable bowel syndrome and other conditions. This study found anandamide controls receptors associated with migraines and that this endocannabinoid strongly influences the periaqueductal gray matter, an area known as the “migraine generator” in the brain.
The researchers also found cannabinoids block spinal, peripheral and gastrointestinal actions that promote pain in headache, fibromyalgia, irritable bowel syndrome and other conditions. In other words, increasing cannabinoid levels reduces symptoms associated with clinical endocannabinoid deficiency syndrome.
How Does CBD Affect the Endocannabinoid System?
The endocannabinoid system exists to respond to endogenous cannabinoids produced by the human body. However, scientists have learned that the system will also recognize and respond to cannabinoids from external sources, including the phytocannabinoid cannabidiol. According to the National Institutes of Health, manipulating the endocannabinoid system by introducing external cannabinoids like CBD could be useful in treating a variety of medical ailments.
CBD and Cannabinoid Receptors
The endocannabinoid system includes two primary types of receptors that bind to cannabinoids: CB1 and CB2. Unlike THC, which fits directly into the CB1 receptor, cannabidiol does not fit into either type of receptor perfectly. Instead, it stimulates activity in both receptors without actually binding to them. This results in changes within any cells that contain either receptor. Because CB1 and CB2 receptors are present throughout the body, the effects of CBD are systemic.
According to Project CBD, research has also shown that CBD counteracts the psychoactive effects of THC by inhibiting its effects on CB1 receptors.
CBD’s Indirect Effects on the Endocannabinoid System
When introduced into the endocannabinoid system, CBD causes an increased release of 2-AG, one of the endogenous cannabinoids. Like CBD, 2-AG stimulates both CB1 and CB2 receptors, which enhances the overall effect on the body. Studies published by the National Institutes of Health have shown that cannabidiol also inhibits the activity of fatty acid amide hydroxylase, or FAAH. This slows the deterioration of anandamide, another important endogenous cannabinoid found naturally within the body.
Other Effects of CBD
In addition to its impact on the endocannabinoid system, CBD also affects the body in other ways. For example, CBD binds directly to a G-protein coupled receptor known as TRPV-1, which is responsible for mediating body temperature, perceptions of pain and inflammation. CBD also activates serotonin receptors. Furthermore, studies conducted by the California Pacific Medical Center have shown that cannabidiol has the power to inhibit the ID-1 gene, which is known to cause several aggressive cancers, including certain cancers of the breast, brain, lungs, ovaries and pancreas.
Implications in Medicine
Cannabidiols impact on the endocannabinoid system, as well as its other effects on the human body, indicate that this substance may be useful in treating a variety of medical conditions. For example, the medical community has already identified that THC can be an effective treatment for multiple ailments, including the side effects of chemo. Because CBD inhibits the negative effects of THC, it stands to reason that administering the two substances together could be even more beneficial than treatment with THC alone. Likewise, cannabidiols stimulation of the endocannabinoid system promotes homeostasis within the body, reduces sensations of pain and inhibits inflammatory processes. Finally, CBD’s effects on other genes and systems, such as its inhibition of the ID-1 gene, indicate that it may be an ideal treatment for certain types of effective cancers.
General Advice on CBD Dosage
CBD-rich hemp oil comes in various concentrations and forms, including liquid hemp oil, hemp oil as a thick paste, oil in capsules, sublingual tincture drops or sprays, salves for topical use, edibles as in chocolate bars or gummy bears and CBD vapor from vaporizers similar to e-cigarettes.
Everyone Is Different
This is only meant to be a guideline, a starting point of reference. The fact remains that everyone is in a different place and will react differently to their CBD dosage. As serving size or dosage of CBD differs for each person, it is best to start small and gradually increase until you experience the desired result.
CBD Brands Confusing Dosage
CBD oil brands create a lot of confusion for consumers because they all have different standards. Many of them recommend way too much as a “serving” and others recommend too little. Serving Standard is 15-30mg of CBD to be taken in the morning, and 30-60mg in the evening.
It is also recommended that you try increasing dosage every 3-4 weeks by upto 40mg a day until symptom relief. Decrease amount of CBD with any worsening of symptoms.
CBD Oil Dosing
Concentrations vary between preparations, ranging from 1 mg per dose to hundreds of milligrams. This makes it easy for consumers to get the dosages they need in a form they find easy to use.
CBD dosages are based on scientific research, publications, traditional use, or expert opinion. Cannabinoid dosages and duration of treatment depend largely on the disease. These are only a guideline.
How Much CBD Oil Should I Take?
Chronic Pain: 10 - 35 mg of CBD under the tongue.
Epilepsy: 150 - 300 mg of CBD under the tongue daily.
Movement Problems / Huntington’s Disease: per kilogram; 10 mg of CBD by mouth daily.
Sleep Disorders: 40 - 160 mg of CBD under the tongue.
Schizophrenia: 40 - 1,280 mg of CBD under the tongue daily.
Glaucoma: 20-40 mg under the tongue; Doses greater than 40 mg may actually increase eye pressure.
According to CannLabs, Americas top full-service testing lab for cannabis products, there is no established lethal CBD dose. ie: No-one has ever died taking cannabis related products.
How to Use CBD Oil
CBD is most commonly taken orally in a concentrated paste or drops / tincture format. To take CBD oil first hold it under the tongue to be absorbed in the mouth prior to swallowing. This step is important because some of the CBD taken will be broken down by the digestive system. Other oral methods include sprays, capsules, and edibles such as chocolate bars and gummy bears. Many people also enjoy using CBD oil via vaporizers as this is a near instant delivery method that can be quite effective. Others use CBD oil by taking it through the skin via balms or creams. There are many ways to take CBD oil, what matters most is trying a few different approaches and seeing what works. Again, everyone is different.
The Biphasic Properties of CBD
Research has shown that cannabidiol has a myriad of effects on the human body. Because of its numerous positive effects, CBD Cannabidiol can be used to treat many different conditions safely. However, when a patient consumes CBD, following proper dosing instructions is extremely important. Cannabidiol is has biphasic properties and may not produce the desired effect if the dose consumed is too high or too low.
A biphasic drug is one that has differing effects on the body at different blood concentration levels. One of the most well known biphasic drugs is alcohol, which acts as a stimulant until blood alcohol levels reach 0.05 percent. After this point, continued consumption of alcohol causes sedation and depression.
Cannabidiol’s Biphasic Response
According to John Hicks, MD, cannabidiols initial effect is stimulating. When CBD interacts with the endocannabinoid system at lower levels, it has been shown to increase wakefulness, alertness and other such traits among patients. Low doses of CBD can also contribute to elevated mood. At higher doses, however, CBD has a sedating effect instead. For example, people who consume larger amounts of CBD may feel sleepy and calm, as opposed to alert and energetic.
Implications in Treatment
Because of cannabidiols biphasic properties, it can be used to treat a large variety of problems on both ends of the spectrum, from insomnia to depression. However, in order to effectively treat a specific problem, the proper dose of CBD must be consumed. For example, research published by cannabisclinicians.org reports that patients who received only 15 mg of cannabidiol reported feeling more clear-minded and alert. Studies also showed that patients receiving a 15 mg dose of cannabidiol experienced more wakefulness during sleep than those who did not take CBD. On the other hand patients receiving 300 mg doses of cannabidiol reported feeling more sedated. Furthermore, even at a dose of 150 mg, studies show that cannabidiol increases sleep duration. Again, everyone is different.
Stonelabz CBD products contain:
Please allow for slight variations in the percentage values.
Contains Low Concentrations of (CBC, CBG, CBN).
CBD and other compounds are the Natural Constituent of The Hemp Plant.
Other Natural Molecules in Hemp:
Plant Waxes, Alkanes, Nitrogenous compounds, Amino acids, Sugars, Aldehydes, Alcohols, Ketones, Flavanoids, Terpenoids, Glycosides, Vitamins, Pigments & Water.
Stonelabz products are produced and packaged in The Canary Islands; Tenerife, Spain.
Made from Industrial Hemp that is:
Only the highest quality baking and extraction techniques are used together with the finest quality organic ingredients to ensure the exceptional quality of each and every one of our products.
Food; Store away from sunlight, heat and humidity. Refrigerate after opening.
Allow the oil to reach room temperature before administering.
Place bottle in warm water if you have difficulty with administration.
WARNING: ALWAYS READ ENCLOSED INSTRUCTIONS ACCOMPANYING ALL OUR PRODUCTS
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